Welcome to our
bioprocessing & sustainability blog
Discover the latest insights, industry trends, and expert perspectives. From breakthrough innovations to behind-the-scenes stories, our articles keep you informed and inspired - because great ideas deserve a spotlight!
Elisabetha Larionova
August 11, 2026
98 × 10⁸ cells collected, but 7 in 10 patients remain out of reach: The hidden numbers behind cell therapy development
From millions of collected cells to billions required for a therapy, achieving the right cell density determines whether a CGT reaches patients.
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Elisabetha Larionova
July 30, 2026
Green Elephant Biotech secures INNOWWIDE Grant to test automated adherent MSC manufacturing for the U.S. market
Green Elephant Biotech has secured an INNOWWIDE market feasibility grant from the German Federal Ministry of Research, Technology and Space (BMFTR). The grant funds a feasibility study, ... Read more
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Mira Sternstein
July 16, 2026
Green Elephant Biotech is a partner in S.O.L.A.R.I.S. advancing scalable and sustainable CAR T cell manufacturing across Europe
S.O.L.A.R.I.S., a new EU-funded project by Horizon Europe, will develop and test novel approaches to CAR T cell manufacturing to improve patient access to therapies across Europe.
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Elisabetha Larionova
July 14, 2026
Green Elephant Biotech opens indicative pricing for Archimedes® One Bioreactor ahead of commercial launch
Green Elephant opens pre-orders and shares indicative pricing on request for customers interested in dynamic adherent bioreactor.
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Elisabetha Larionova
July 14, 2026
Does the cell and gene therapy development have to take 8 protracted years, or are we unknowingly leaving speed on the table?
Despite the clinical potential, cell and gene therapy development remains constrained not by biology but by manufacturing infrastructure, salvageable by automation, closed bioprocessing, and quality-by-design approaches.
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Elisabetha Larionova
June 16, 2026
Scaling macrophage manufacturing beyond T-175 flasks and multi-layer stacks — a high-impact crisis behind many cell therapies
Macrophage manufacturing faces scalability and compliance barriers rooted in adherence dependency — challenges, solvable through closed bioprocessing and purpose-built culture systems.
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Elisabetha Larionova
May 5, 2026
Stem cells and the patient: Critical milestones achieved since COVID-19 and those still to come
Stem cells hold remarkable patient-centric promise, though tumorigenicity risks, reprogramming inefficiencies, and inconsistent characterization standards continue to challenge their safe and large-scale clinical implementation.
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Elisabetha Larionova
April 24, 2026
A comprehensive device compilation for 96-well plates: Microtiter plate readers, liquid handling systems, robotic arms, heat sealing, and more
Microtiter plate readers, liquid handlers, and robotic platforms are actively transforming life science laboratories. Across screening and diagnostics, their benefits primarily affect productivity, reproducibility, and data quality.
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Elisabetha Larionova
April 13, 2026
Automated cell culture systems: How automation prevents $100,000 lethal errors
Manual errors in cell culture carry significant financial consequences. Automation delivers measurable gains in robustness, quality control, and scalability for CGT manufacturing.
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Elisabetha Larionova
April 1, 2026
What cell harvesting method to choose: The intricate question that therapy developers and manufacturers still share in 2026
Cell harvesting methods shape cell culture harvest outcomes by balancing efficiency, viability, and sample purity, requiring tailored strategies from centrifugation to advanced techniques to ensure scalable bioprocessing.
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Elisabetha Larionova
March 24, 2026
Navigating a 30-year old debate of single-use vs. reusable culture systems. Would you focus on sterility or sustainability?
The debate behind the advantages of single-use vs. reusable culture systems focuses on sterility and sustainability, meant to guide smarter material choices for modern biomanufacturing.
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Elisabetha Larionova
March 17, 2026
Innovative partnership revolutionizes cell therapy manufacturing by introducing Archimedes® One for enabling scalable, automated adherent cell culture
Gießen and Ingelfingen, Germany – 17.03.2026. Green Elephant Biotech announced the introduction of the Archimedes® One — Dynamic Adherent Bioreactor, a new platform designed to simplify and ... Read more
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Elisabetha Larionova
March 10, 2026
Scaling from 250 mL to 10,000 L: Mixing time and prominent criteria that form the backbone of biomanufacturing
Bioreactor scale-up in biomanufacturing depends on mixing time, oxygen transfer, and hydrodynamics, which are essential to balance alongside biological equivalence of the workflow.
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Elisabetha Larionova
March 4, 2026
Scaling-out — a game-changing manufacturing shift, seen to transform clinical manufacturing in the 21st century
Scaling-out is transforming personalized therapies by replacing the dominant scale-up logic, enabling clinical manufacturing that is aligned with biology-driven design and patient-centered production timelines.
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Elisabetha Larionova
February 24, 2026
Impactful decisions concerning 2 trusted cell harvesting methods: Trypsin vs. accutase
Cell harvesting methods critically influence downstream processing, as trypsin offers scalable efficiency while accutase preserves cell integrity, requiring strategic selection to balance yield, quality, and manufacturing robustness.
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Elisabetha Larionova
February 19, 2026
Expected and unexpected outcomes of a hypoxia culture: The true impact of oxygen levels below 3% on stem cell lines
Hypoxia culture was found to modulate stemness, proliferation, and viability of stem cell lines, identifying its use as a strategy for regenerative therapies.
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Elisabetha Larionova
February 17, 2026
Accelerating the transition to sustainable labware for US customers: Green Elephant Biotech partners with Labscoop in a distribution agreement for plant-based 96-Well PLAtes
Building on the successful adoption of its 96-well microPLAtes across Europe, Green Elephant Biotech, in partnership with Labscoop, is enabling US laboratories to transition from fossil-based consumables ... Read more
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Elisabetha Larionova
February 10, 2026
Microcarriers, microfluidics, and bioreactors – what they offer and what remains to be reformed in 2026?
Bioreactors anchor modern cell cultivation, yet microcarriers and microfluidics reveal limits in scalability and control, highlighting why reforming bioreactors remains critical for the future of bioprocessing.
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Elisabetha Larionova
February 3, 2026
Closed systems in bioprocessing: A proven story behind a 47% reduction in contamination risk through aseptic connectors
Fully closed systems using aseptic connectors enable sterile, flexible bioprocessing, lowering batch failure, simplifying GMP workflows, and support scalable manufacturing in advanced therapies.
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Elisabetha Larionova
January 27, 2026
3 implications of the innovative automated cell culture systems we should recognize
CGT manufacturing faces costs and capacity limits. Strategic adaptation of automated cell culture systems can improve scalability and efficiency, extending the change onto additional aspects of the industry.
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Elisabetha Larionova
January 20, 2026
Open vs. closed systems in cell culture manufacturing: 3 powerful drivers behind the shift to closed processing
Closed systems in cell culture manufacturing reduce contamination risk, improve GMP compliance, and enable scalable manufacturing, addressing cost, variability, and regulatory barriers persistent in the advanced therapy landscape.
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Elisabetha Larionova
January 13, 2026
When science outpaces infrastructure: 4 automation solutions from industry pioneers in cell manufacturing
Cell therapy success increasingly depends on automation, enabling scalable, reproducible manufacturing, reducing regulatory risk, and improving patient access to advanced therapies across GMP settings.
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Elisabetha Larionova
January 5, 2026
Vision for 2026: Innovating the promising future of cell therapies and manufacturing
Entering 2026, Green Elephant Biotech outlines a clear vision to scale adherent cell cultures sustainably, advance GMP-ready innovation, and partner globally to re-shape biomanufacturing workflows efficiently.
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Elisabetha Larionova
December 26, 2025
3 out of many challenges associated with Advanced Therapy Medicinal Products (ATMPs)
Advanced Therapy Medicinal Products promise transformative medicine, though regulatory complexities, manufacturing variability, and fragmented reimbursement continue to limit patient access across Europe despite latest scientific progress.
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Elisabetha Larionova
December 12, 2025
How LCA and Scope 3 emissions guide the biotech industry toward a global climate solution
See how leveraging LCA and Scope 3 emissions accounting enables applicable quantification of greenhouse gas footprints, empowering researchers to design more sustainable bioprocesses and products.
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Elisabetha Larionova
December 10, 2025
Green Elephant Biotech to pursue My Green Lab® ACT® Ecolabel 2.0 product certification
Green Elephant Biotech, a German-based company developing, manufacturing, and marketing plant-based laboratory consumables, will pursue certification under the My Green Lab® ACT® Ecolabel 2.0 Program.
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Elisabetha Larionova
December 5, 2025
Luminescence assays: Key reasons to opt in for a white 96-well microtiter plate
Luminescence assays rely on light detection, where white plates enhance signal quality. Choosing correct microtiter plate and sustainable PLA options improves performance across luminescence and further assays.
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Elisabetha Larionova
November 28, 2025
The captivating world of cell banking: Purpose, applications, and concealed issues
Cell banking provides homogeneous cell sources essential for CGT development, yet its broad applications also raise ethical concerns, particularly within private cell banking.
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Elisabetha Larionova
November 20, 2025
2 powerful causes for the rise in cell production: Therapy products vs. producer organisms
Personalized medicine relies on therapy products made from a patient’s own cells or engineered lines. Both paths converge on one substantial challenge: scalable adherent cell culture manufacturing.
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Elisabetha Larionova
November 13, 2025
Mimicking cell growth conditions in incubators – 5 crucial factors to maintain cell culture in vitro
From ancient egg chambers to precision CO₂ incubators, controlling temperature, gases, and humidity remains vital for mimicking the body’s environment. Proper growth conditions ensure health, reproducibility, and economical efficiency.
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Elisabetha Larionova
November 6, 2025
Is cell microscopy essential or arbitrary in 2025 science labs and beyond?
From lenses to sensors: Modern cell monitoring moves beyond microscopy, embracing real-time low-impact technologies that can reveal cell viability with greater precision, scalability, and relevance.
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Elisabetha Larionova
October 22, 2025
HEK-293 cells in CGTs: Key challenges, accelerating production, and strategic innovation
HEK-293 cells have become a valuable asset of modern biomanufacturing, enabling the production of complex cell and gene therapies. Read about novel solutions that redefine HEK-293 seed train expansion and optimize upstream bioprocessing.
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Elisabetha Larionova
September 30, 2025
The 3 effective cell cultivation systems: A flask, a roller bottle, or a stack?
Flasks, roller bottles, and multilayer systems remain central in adherent cell culture, yet each cultivation systems faces scalability challenges. New platforms like CellScrew® aim to streamline expansion, efficiency, and sustainability.
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Joel Eichmann
August 11, 2025
What are single-use systems in bioprocessing?
Single-use systems streamline biopharma production, boosting flexibility and reducing contamination - ideal for Cell and Gene therapies.
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Mira Sternstein
August 7, 2025
Coatings in adherent cell culture
Cell culture coatings enhance adhesion and growth beyond TC treatment. Defined coatings improve consistency and quality, supporting reliable cell expansion for clinical-grade production and CGT manufacturing.
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Mira Sternstein
August 5, 2025
Tissue culture treatment (TC treatment): Why TC-treated surfaces matter in cell culture
Tissue culture treatment optimizes surfaces for cell adhesion and growth. TC-treated vessels improve standard and specialized cell expansion, supporting consistent quality in regenerative medicine and CGT manufacturing.
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Katharina Günther
July 31, 2025
Stem cell therapy benefits – repair, replace, restore
Stem cell therapy benefits include repairing, replacing, and restoring damaged tissues. iPSC and MSC therapies offer regenerative solutions, transforming treatment options for heart, eye, and immune-related diseases.
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Lukas Käßer
July 24, 2025
Shear forces and the influence of shear stress on cell culture processes
Shear stress in cell culture affects MSC and iPSC growth, differentiation, and viability, making its control crucial for Cell and Gene Therapy success.
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Lukas Käßer
July 8, 2025
What is Fused Deposition Modeling and what are the applications of 3D manufacturing in life sciences
3D manufacturing is reshaping life sciences by enabling customized, precise, and scalable solutions. Its adaptability supports innovation in research tools, prototyping, and product development using advanced materials.
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Annika Herchenröder
June 27, 2025
Choosing the best 96-well plate for fluorescence assays: Why black ones are key?
Accurate fluorescence measurement is crucial in many assays. Black well plates optimize performance by minimizing light scatter and reflection, supporting reliable and reproducible results in lab environments.
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Annika Herchenröder
June 25, 2025
Can PLA well plates replace polystyrene plates for a greener future?
Well plates are widely used in biopharma, creating single-use waste. Replacing polystyrene (PS) with PLA improves sustainability and reduces carbon emissions by up to 50%.
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Mira Sternstein
June 23, 2025
Seed train in cell culture: foundation of scalable biomanufacturing
From cell therapy to vaccine and biologics manufacturing, seed trains are essential for building up biomass in cell culture — but current approaches face serious scale-up limitations.
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Joel Eichmann
June 19, 2025
Cell culture challenges: Contamination & prevention
Maintaining clean cell cultures is essential in research and GMP manufacturing. Contamination sources, types, and prevention methods significantly affect bioprocessing outcomes.
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Felix Wollenhaupt
June 13, 2025
Personalized therapy: Revolutionizing biopharma production and application
Biopharma manufacturing is transforming as personalized therapies, especially Cell and Gene Therapeutics, reshape products and demand new tools and processes.
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Joel Eichmann
June 4, 2025
GMP compliance in Cell Therapy & AAV manufacturing
GMP plays a critical role in cell therapy and AAV manufacturing, with critical quality attributes (CQA essential for ensuring product quality, safety, and clinical effectiveness.
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Mira Sternstein
May 28, 2025
Adherent and suspension cell culture
Adherent and suspension cell cultures differ in scalability, handling, and application—each plays a distinct role in biopharmaceutical manufacturing, impacting process design, efficiency, and production outcomes.
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Mira Sternstein
May 26, 2025
Why the scale-up of cell culture is essential for manufacturing Cell and Gene therapies
Efficient bioreactor scale-up of cell culture is key to CGT commercialization—enabling consistent, safe, and compliant production from research to market without costly delays.
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Felix Wollenhaupt
May 22, 2025
Investing in European bioreactors: A convergence of scientific impact and market growth
The European bioreactors market is set to reach €3.34B by 2032, fueled by CGT demand, cost-efficient single-use systems, investor momentum, and EU policy support.
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Lukas Käßer
May 20, 2025
The relevance of the oxygen transfer rate for successful cell cultivation
The kLa value quantifies oxygen transfer efficiency in bioreactors and serves as a key parameter and scale-up factor in optimizing biopharmaceutical manufacturing processes and outcomes.
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Mira Sternstein
May 16, 2025
Bioreactors – function, application, and challenges
Bioreactors support efficient cell culture, fermentation, and scale-up—essential technologies driving success in biopharmaceutical production, regenerative medicine, and industrial bioprocessing applications.
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