Welcome to our
bioprocessing & sustainability blog
Discover the latest insights, industry trends, and expert perspectives. From breakthrough innovations to behind-the-scenes stories, our articles keep you informed and inspired - because great ideas deserve a spotlight!
August 11, 2026
98 × 10⁸ cells collected, but 7 in 10 patients remain out of reach: The hidden numbers behind cell therapy development
From millions of collected cells to billions required for a therapy, achieving the right cell density determines whether a CGT reaches patients.
July 14, 2026
Does the cell and gene therapy development have to take 8 protracted years, or are we unknowingly leaving speed on the table?
Despite the clinical potential, cell and gene therapy development remains constrained not by biology but by manufacturing infrastructure, salvageable by automation, closed bioprocessing, and quality-by-design approaches.
June 16, 2026
Scaling macrophage manufacturing beyond T-175 flasks and multi-layer stacks — a high-impact crisis behind many cell therapies
Macrophage manufacturing faces scalability and compliance barriers rooted in adherence dependency — challenges, solvable through closed bioprocessing and purpose-built culture systems.
May 5, 2026
Stem cells and the patient: Critical milestones achieved since COVID-19 and those still to come
Stem cells hold remarkable patient-centric promise, though tumorigenicity risks, reprogramming inefficiencies, and inconsistent characterization standards continue to challenge their safe and large-scale clinical implementation.
April 13, 2026
Automated cell culture systems: How automation prevents $100,000 lethal errors
Manual errors in cell culture carry significant financial consequences. Automation delivers measurable gains in robustness, quality control, and scalability for CGT manufacturing.
April 1, 2026
What cell harvesting method to choose: The intricate question that therapy developers and manufacturers still share in 2026
Cell harvesting methods shape cell culture harvest outcomes by balancing efficiency, viability, and sample purity, requiring tailored strategies from centrifugation to advanced techniques to ensure scalable bioprocessing.
March 24, 2026
Navigating a 30-year old debate of single-use vs. reusable culture systems. Would you focus on sterility or sustainability?
The debate behind the advantages of single-use vs. reusable culture systems focuses on sterility and sustainability, meant to guide smarter material choices for modern biomanufacturing.
March 10, 2026
Scaling from 250 mL to 10,000 L: Mixing time and prominent criteria that form the backbone of biomanufacturing
Bioreactor scale-up in biomanufacturing depends on mixing time, oxygen transfer, and hydrodynamics, which are essential to balance alongside biological equivalence of the workflow.
March 4, 2026
Scaling-out — a game-changing manufacturing shift, seen to transform clinical manufacturing in the 21st century
Scaling-out is transforming personalized therapies by replacing the dominant scale-up logic, enabling clinical manufacturing that is aligned with biology-driven design and patient-centered production timelines.
February 24, 2026
Impactful decisions concerning 2 trusted cell harvesting methods: Trypsin vs. accutase
Cell harvesting methods critically influence downstream processing, as trypsin offers scalable efficiency while accutase preserves cell integrity, requiring strategic selection to balance yield, quality, and manufacturing robustness.
February 19, 2026
Expected and unexpected outcomes of a hypoxia culture: The true impact of oxygen levels below 3% on stem cell lines
Hypoxia culture was found to modulate stemness, proliferation, and viability of stem cell lines, identifying its use as a strategy for regenerative therapies.
February 10, 2026
Microcarriers, microfluidics, and bioreactors – what they offer and what remains to be reformed in 2026?
Bioreactors anchor modern cell cultivation, yet microcarriers and microfluidics reveal limits in scalability and control, highlighting why reforming bioreactors remains critical for the future of bioprocessing.
February 3, 2026
Closed systems in bioprocessing: A proven story behind a 47% reduction in contamination risk through aseptic connectors
Fully closed systems using aseptic connectors enable sterile, flexible bioprocessing, lowering batch failure, simplifying GMP workflows, and support scalable manufacturing in advanced therapies.
January 20, 2026
Open vs. closed systems in cell culture manufacturing: 3 powerful drivers behind the shift to closed processing
Closed systems in cell culture manufacturing reduce contamination risk, improve GMP compliance, and enable scalable manufacturing, addressing cost, variability, and regulatory barriers persistent in the advanced therapy landscape.
January 13, 2026
When science outpaces infrastructure: 4 automation solutions from industry pioneers in cell manufacturing
Cell therapy success increasingly depends on automation, enabling scalable, reproducible manufacturing, reducing regulatory risk, and improving patient access to advanced therapies across GMP settings.
November 28, 2025
The captivating world of cell banking: Purpose, applications, and concealed issues
Cell banking provides homogeneous cell sources essential for CGT development, yet its broad applications also raise ethical concerns, particularly within private cell banking.
November 13, 2025
Mimicking cell growth conditions in incubators – 5 crucial factors to maintain cell culture in vitro
From ancient egg chambers to precision CO₂ incubators, controlling temperature, gases, and humidity remains vital for mimicking the body’s environment. Proper growth conditions ensure health, reproducibility, and economical efficiency.
October 22, 2025
HEK-293 cells in CGTs: Key challenges, accelerating production, and strategic innovation
HEK-293 cells have become a valuable asset of modern biomanufacturing, enabling the production of complex cell and gene therapies. Read about novel solutions that redefine HEK-293 seed train expansion and optimize upstream bioprocessing.
September 30, 2025
The 3 effective cell cultivation systems: A flask, a roller bottle, or a stack?
Flasks, roller bottles, and multilayer systems remain central in adherent cell culture, yet each cultivation systems faces scalability challenges. New platforms like CellScrew® aim to streamline expansion, efficiency, and sustainability.
August 11, 2025
What are single-use systems in bioprocessing?
Single-use systems streamline biopharma production, boosting flexibility and reducing contamination - ideal for Cell and Gene therapies.
August 7, 2025
Coatings in adherent cell culture
Cell culture coatings enhance adhesion and growth beyond TC treatment. Defined coatings improve consistency and quality, supporting reliable cell expansion for clinical-grade production and CGT manufacturing.
August 5, 2025
Tissue culture treatment (TC treatment): Why TC-treated surfaces matter in cell culture
Tissue culture treatment optimizes surfaces for cell adhesion and growth. TC-treated vessels improve standard and specialized cell expansion, supporting consistent quality in regenerative medicine and CGT manufacturing.
July 31, 2025
Stem cell therapy benefits – repair, replace, restore
Stem cell therapy benefits include repairing, replacing, and restoring damaged tissues. iPSC and MSC therapies offer regenerative solutions, transforming treatment options for heart, eye, and immune-related diseases.
July 24, 2025
Shear forces and the influence of shear stress on cell culture processes
Shear stress in cell culture affects MSC and iPSC growth, differentiation, and viability, making its control crucial for Cell and Gene Therapy success.
July 8, 2025
What is Fused Deposition Modeling and what are the applications of 3D manufacturing in life sciences
3D manufacturing is reshaping life sciences by enabling customized, precise, and scalable solutions. Its adaptability supports innovation in research tools, prototyping, and product development using advanced materials.
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