CellScrew® cultivation data & documents
Explore the core of CellScrew® with application notes (AN), brochures, and technical data sheets. Find specifications, insights for optimized cell cultivation, and performance data, such as CHO-K1 cell densities of 125,000 cells/cm² and kLa values.
More documents in our library
Differentiated macrophages in CellScrew® mini and 6K
following differentiation in CellScrew® mini; dPCR readout expressed as
copies/μL normalized to HKG; R² = 0.9812.
Macrophage production for MAT assay application
New customer data
The first external evaluation of macrophage production in CellScrew® conducted by Minerva Biolabs.
Human monocytes differentiated into functional NAT-MAT® Cells could be harvested and tested for across two scales, CellScrew® mini and 6K. Differentiation and pyrogen response assessed independently, with IL-1β and TNF-α induction confirmed by dPCR for MAT applications.
Download Application Note
Human monocytes differentiated into functional NAT-MAT® Cells could be harvested and tested for across two scales, CellScrew® mini and 6K. Differentiation and pyrogen response assessed independently, with IL-1β and TNF-α induction confirmed by dPCR for MAT applications.
Harvest of B16-F10 and
CT-26 in the CellScrew® mini
Characterization of novel bioreactor
New peer-reviewed publication
The CellScrew® supports robust adherent growth across cell types — HEK-293, B16-F10, and CT-26 WT — while reducing vessel count, lowering reagent use, and minimizing handling steps. A peer-reviewed evaluation of hydrodynamics, oxygen transfer, cell attachment, proliferation, harvest performance, and metabolite profiles across manufacturing-relevant conditions.
Download Research Paper
Harvest of recombinant protein in 51-day culture period of HEK-293
Recombinant protein production in HEK-293
Long-term recombinant protein production in stably transfected HEK-293 cells cultured in the CellScrew® mini over a 51-day period, demonstrating consistent protein concentration and sustained metabolic activity with zero contamination events. This study establishes the CellScrew® mini as a robust and reliable platform for long-term protein production, from process development through to clinical manufacturing.
Download Poster
Cultivation of CHO-K1 in the CellScrew® mini
Growing adherent CHO-K1 in the CellScrew® mini
Cultivation of CHO-K1 cells on the CellScrew® PLA surface enables expected growth and performance comparable to standard 2D culture systems while maintaining established cell characteristics.
- expected cell density of 125,000 cells/cm² reached after 3 days
- comparable CHO-K1 cell yields to standard 2D culture systems
- retained cell characteristics consistent with PS-based workflows
Application of PLA as a growth surface for adherent cells
The sustainable plant-based growth surface shows cell attachment and growth comparable to standard polystyrene surfaces.
- successful expansion, exceeding DSMZ data
- high harvesting efficiency with reduced enzyme concentration
Cultivation and Expansion of HEK-293 cells in the CellScrew® 6K
Comparison of handling time of the CellScrew® 6K and competitors
Reduction of manual handling time
The efficient design of the CellScrew® enhances processes and results in a reduced handling time compared to competitors, independently of the operator.
- comparable handling times across operators
- reduced handling time
- enhanced process leading to reduced working time
Process Engineering Characterization of the CellScrew® 6K and 10K
Mixing time and oxygen transfer coefficient
Comparison of mixing time and oxygen transfer coefficient (kLa-value) at different rotational speeds for the CellScrew®.
- Short mixing times
- Comparable kLa value to benchtop bioreactor system
There’s more to discover!
Find our growing set of performance data, application studies and supporting documents in our document library.
Looking for peer-reviewed data and our latest posters? Find them on our scientific publications page.
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