Macrophage manufacturing: Protecting function through harvest

Macrophage manufacturing: Protecting function through harvest

Macrophages serve two main roles in industry: as an in vitro test system for detecting pyrogens and as a therapeutic. While their applications differ, their manufacturing depends on the same three requirements: scale adherent surface area without a switch to suspension, put harvest quality and functional integrity ahead of expansion yield, and detach cells gently.

This white paper covers:

  • How adherent growth, post-mitotic biology and harvest sensitivity set platform requirements
  • Why harvest is closer to a functional test than a transfer step
  • How manufacturing variability played out in MATCH01, a phase 2 macrophage therapy trial
  • Functional data from large-scale adherent culture, at two vessel scales
  • Monocyte-derived and iPSC-derived macrophages compared
  • A five-question framework for testing a platform decision early
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Categories: White paper
TITLE GreenElephantBiotech Whitepaper Macrophage Scaling V1

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